Why the study?
Does acute volume loading increase left ventricular contractility via calcium release from the sarcoplasmic reticulum in anesthetized dogs?
Population
18 anesthetized dogs with denervated hearts paced at 100 +/- 9 beats/min
Comparison
Acute volume loading with or without verapamil… vs Baseline or control conditions
Design
Preclinical
Follow-up
10 minutes
Authors
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Supports SR Ca release in volume-induced LV contractility in dogs; leaves open translation to human physiology or therapy.
Does acute volume loading increase left ventricular contractility via calcium release from the sarcoplasmic reticulum in anesthetized dogs?
Acute volume loading produces a time-dependent increase in LV contractility mediated partly by sarcoplasmic reticulum calcium release.
Wilbur Y.W. Lew (1993) studied this question.
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