Effects of chronic volume overload on left ventricular response to tachycardia

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Population

18 dogs (10 normal dogs and 8 dogs with a chronic left ventricular volume overload induced by aortocaval…

Comparison

Tachycardia and administration of AR-L115 BS… vs Normal dogs

Design

Preclinical

Authors

Discussion

May augment contractility with tachycardia in volume overload; hypothesis-generating in dogs and leaves open human translation.

Population

18 dogs (10 normal dogs and 8 dogs with a chronic left ventricular (LV) volume overload induced by aortocaval fistula)

Intervention

Tachycardia (increasing heart rate by stimulation) and administration of AR-L115 BS, propranolol, and atropine

Comparator

Normal dogs

Outcome

Inotropic response of the left ventricle to a change in frequency of stimulation (peak +dP/dt and (dP/dt)/DP40)surrogate

Chronic left ventricular volume overload enhances the positive inotropic effects of tachycardia in a canine model.

Pouleur et al. (1983) studied this question.

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