August 12, 2006AJP Heart and Circulatory Physiology

Left ventricular pressure-volume relationship in conscious mice

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Population

17 male mice (age, 11-20 wk)

Comparison

Measurement of left ventricular pressure-volume… vs Baseline state

Design

Preclinical

Authors

SJShuji JohoUniversity of Toyama SIShinji IshizakaRikkyo University RSRichard E. SieversHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Supports serial LV assessment in conscious mice; extends genetic-hemodynamic tools while leaving clinical translation open.

Structured PICO

Population

17 male mice (age, 11-20 wk)

Intervention

Measurement of left ventricular pressure-volume relationship using a conductance catheter inserted into the LV through an implanted polyethylene tube in the conscious state, with pharmacological modulation (isoproterenol, atenolol, isoflurane)

Comparator

Baseline state

Outcome

Load-independent parameters of contractility (slope of the end-systolic pressure-volume relationship [E(es)], slope of the maximum first derivative of LV pressure [dP/dt(max)]-end-diastolic volume [EDV] relation, and preload-recruitable stroke work [PRSW])surrogate

This study demonstrates the feasibility of serially assessing left ventricular pressure-volume relationships in conscious mice without anesthesia, providing a valuable tool for genetic-hemodynamic research.

Cite This Study

Joho et al. (2006) studied this question.

synapsesocial.com/papers/6a71466b2163a0a01bc56e70 https://doi.org/10.1152/ajpheart.00704.2006

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Ask AI

Bookmark

Left ventricular pressure-volume relationship in conscious mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Left ventricular pressure-volume relationship in conscious mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider