Why the study?
Does anesthesia with ketamine/xylazine compared to isoflurane affect postoperative left ventricular function recovery in conscious mice?
Population
25 mice undergoing surgery for implantation of tubing in the left ventricular cavity
Comparison
Anesthesia with intraperitoneal injection of… vs Anesthesia with isoflurane by inhalation
Design
Preclinical
Follow-up
1 week
Authors
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Ketamine/xylazine may transiently impair LV recovery in mice; leaves open optimal anesthesia selection for cardiovascular research.
Does anesthesia with ketamine/xylazine compared to isoflurane affect postoperative left ventricular function recovery in conscious mice?
A new method for measuring LV pressure in conscious mice reveals that ketamine/xylazine anesthesia depresses LV function for up to 3 days post-surgery compared to isoflurane.
Ishizaka et al. (2004) studied this question.
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