October 11, 2013Journal of Applied PhysiologyOpen Access

Chronic measurement of left ventricular pressure in freely moving rats

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Population

Conscious freely moving rats (n=7)

Design

Preclinical

Follow-up

up to 85 days

Authors

ESEllyce StehlinUniversity of Auckland SMSimon C. MalpasUniversity of Auckland DBDavid BudgettUniversity of Auckland

Discussion

Member takes

Implication

May improve preclinical cardiac drug testing in rats; leaves open clinical translation of chronic telemetry.

Structured PICO

Population

Conscious freely moving rats (n=7)

Intervention

Implantation of a high-fidelity, solid-state pressure-sensor telemetry device (2-Fr catheter tip in LV chamber, telemeter body in abdomen) for chronic measurement of LVP and dP/dt, with pharmacological challenges (isoproterenol, dobutamine, verapamil, levosimendan)

Outcome

Long-term stability, sensitivity to circadian variation, and ability to measure drug-induced changes in LVP and dP/dtsurrogate

A novel telemetry device enables reliable, chronic measurement of left ventricular pressure and contractility in conscious rats, providing a valuable tool for preclinical cardiovascular research.

Cite This Study

Stehlin et al. (2013) studied this question.

synapsesocial.com/papers/6a91b137ba3535a4ddf59552 https://doi.org/10.1152/japplphysiol.00683.2013

View Full Paper

Ask AI

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Chronic measurement of left ventricular pressure in freely moving rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Chronic measurement of left ventricular pressure in freely moving rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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