Key result
A noninvasive transthoracic accelerometer strongly correlated with invasive LV dP/dt(max) changes after dobutamine in normal (r=0.88, P<0.001) and failing (r=0.89, P<0.001) minipig hearts.
Why the study?
Does a noninvasive transthoracic accelerometer accurately measure LV contractility compared to invasive LV dP/dt in a minipig model of heart failure?
Population
Adult male minipigs before and after development of pacing-induced heart failure
Comparison
Noninvasive assessment of LV contractility using… vs Invasive assessment of LV contractility using LV…
Design
Preclinical
Authors
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May facilitate noninvasive contractility monitoring in preclinical HF; leaves open human validation and clinical adoption.
Does a noninvasive transthoracic accelerometer accurately measure LV contractility compared to invasive LV dP/dt in a minipig model of heart failure?
Effect estimate: r = 0.88 (normal), r = 0.89 (failing)
p-value: p=<0.001
A novel noninvasive transthoracic accelerometer strongly correlates with invasive LV dP/dt for assessing myocardial contractility and contractile reserve in a minipig model of heart failure.
Gemignani et al. (2010) studied Chronic heart failure (n=6). Noninvasive force sensor (accelerometer) vs. Invasive LV dP/dt (Millar catheter) was evaluated on Correlation between noninvasive sensor-based cardiac force changes and invasive positive peak LV dP/dt(max) changes (r = 0.88 (normal), r = 0.89 (failing), p=<0.001). A noninvasive transthoracic accelerometer strongly correlated with invasive LV dP/dt(max) changes after dobutamine in normal (r=0.88, P<0.001) and failing (r=0.89, P<0.001) minipig hearts.
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