What question did this study set out to answer?

To develop a synthesis method for hexa-1,5-diene-3,4-diamines using cobalt-catalyzed double allylic amination.

Diastereo- and Enantioselective Synthesis of Hexa-1,5-diene-3,4-diamines by Cobalt-Catalyzed Asymmetric Double Allylic Amination

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To develop a synthesis method for hexa-1,5-diene-3,4-diamines using cobalt-catalyzed double allylic amination.
Utilized cobalt catalysts to perform asymmetric double allylic substitution.
Synthesized acyclic and cyclic products from hexa-1,5-diene-3,4-diyl dimethyl dicarbonate.
Measured yields, diastereomeric ratios, and enantiomeric excess in the final products.
Achieved up to 96% yield with greater than 20:1 diastereomeric ratio.
Obtained enantiomeric excess of normally 99% in the products.
Cobalt exhibited higher reactivity compared to rhodium and iridium based on substrate structure.

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Randomized trial demonstrates high diastereo- and enantioselectivity in hexa-1,5-diene-3,4-diamines, suggesting new synthetic strategies.

Qu et al. (2026) studied this question.

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