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This research aims to develop a sustainable method for synthesizing 1,4-diamides using cobalt catalysis.

May 18, 2026Open Access

Cobalt-catalyzed synthesis of 1,4-diamides from alkynes promoted by light

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Randomized trial demonstrates efficient synthesis of 1,4-diamides from alkynes, highlighting environmentally friendly catalysis.

This research aims to develop a sustainable method for synthesizing 1,4-diamides using cobalt catalysis.
Cobalt-catalyzed double hydroaminocarbonylation of alkynes
Utilized unmodified cobalt carbonyl catalyst under mild conditions
Applied visible light irradiation to promote the reaction.
Successfully synthesized unsymmetric 1,4-diamides with near perfect regioselectivities using different amine nucleophiles.
Displayed broad substrate scope for both alkyne and amine components.

Dylan Hsu (2026) studied this question.

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