Key result
Human anti-mouse antibody interference causes false-positive BNP in a low-risk PE patient.
Why the study?
Commercial B-type natriuretic peptide immunoassays can be subject to interference from various factors, leading to potentially misleading results.
Case Report (n=1)
Clinicians should consider assay interference from human anti-mouse antibodies when BNP results are surprisingly high and inconsistent with the clinical presentation.
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Unexpected BNP elevations inconsistent with presentation may reflect human anti-mouse antibody interference; this case leaves open its prevalence in routine assays.
Yin et al. (2025) conducted a case report in False-positive B-type natriuretic peptide (n=1). Cyclic amplified fluorescence immunoassay for B-type natriuretic peptide was evaluated on False-positive B-type natriuretic peptide result. A cyclic amplified fluorescence immunoassay produced a false-positive B-type natriuretic peptide result in a patient with low-risk pulmonary embolism due to human anti-mouse antibody interference.
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