Key result
Proposed algorithm identifies heterophile antibody interference in troponin testing to prevent unnecessary hospitalizations.
Why the study?
Heterophile antibodies can interfere in immunological assays measuring cardiospecific troponins, highlighting the need for accurate procedures to distinguish true cardiac damage from false positives and avoid unnecessary tests.
This review provides an algorithm to identify false positive troponin tests caused by heterophile antibodies, helping to prevent unnecessary testing and hospitalizations.
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Proposed algorithm may curb false-positive troponin-driven admissions; leaves open need for prospective validation before adoption.
Salvatici et al. (2025) conducted a review in False positive troponin tests. Algorithm for identifying heterophile antibody interference was evaluated. A proposed algorithm for identifying heterophile antibody interference in troponin testing aims to distinguish true cardiac damage from false positives, preventing unnecessary hospitalizations.
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