Key result
Lipoprotein (a) combined with carotid intima-media thickness significantly improved the prediction of coronary artery disease compared to other lipid parameters (AUC 0.713) and was associated with multi-vessel disease (OR 1.41).
Why the study?
Blood lipids disorder and atherosclerosis are closely related to CAD, and this study aimed to compare different blood lipid parameters combined with cIMT in predicting CAD.
Does Lp(a) combined with cIMT improve the prediction of CAD in patients with highly suspected CAD compared to other lipid parameters?
Observational (n=1,395)
No
Does Lp(a) combined with cIMT improve the prediction of CAD in patients with highly suspected CAD compared to other lipid parameters?
Answers are grounded in this paper and cite their sources.
Lp(a) combined with cIMT enhances the prediction of CAD and multi-vessel CAD in highly suspected patients, particularly when LDL-C is not elevated.
Background: Blood lipids disorder and atherosclerosis are closely related to coronary artery disease (CAD). This study aims to compare different blood lipid parameters combined with carotid intima-media thickness (cIMT) in predicting CAD. Methods: This was a retrospective study including patients who underwent coronary angiography for highly suspected CAD. Blood samples were taken for lipid profile analysis and cIMT was evaluated by carotid ultrasound. Logistic analysis was used to establish different models of different lipid parameters in predicting CAD. The area under the receiver operating characteristic curve (AUC) was used to examine the predictive value. The optimal lipid parameter was also used to explore the relationship with multi-vessel CAD. Conclusion: For patients with highly suspected CAD, Lp (a) better improved the predictive value of CAD rather than most of blood lipid indices, especially in the absence of high levels of LDL-C. Lp (a) also can be used to predict the multi-vessel CAD.
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Yu et al. (2023) conducted an observational in Coronary artery disease (n=1,395). Lipoprotein (a) combined with carotid intima-media thickness vs. Other blood lipid parameters was evaluated on Prediction of coronary artery disease (AUC 0.713, p=<0.001). Lipoprotein (a) combined with carotid intima-media thickness significantly improved the prediction of coronary artery disease compared to other lipid parameters (AUC 0.713) and was associated with multi-vessel disease (OR 1.41).
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