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October 1, 2002Arteriosclerosis Thrombosis and Vascular Biology

Relationship Between Coronary Artery Calcification and Other Measures of Subclinical Cardiovascular Disease in Older Adults

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Why the study?

How do measures of subclinical cardiovascular disease correlate with coronary artery calcium in older adults without clinical cardiovascular disease?

Population

414 community-dwelling older adults without clinical cardiovascular disease from the Cardiovascular Health…

Design

Cross-sectional

Key result

Internal carotid artery intima-media thickness was most strongly correlated with coronary artery calcium (r=0.30) in older adults without clinical cardiovascular disease.

Authors

ANAnne B. NewmanBNBarbara L. NaydeckKSKim Sutton‐Tyrrell

Discussion

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Overview

Internal carotid IMT may aid CAC evaluation in older adults without CVD; leaves open incremental value for risk stratification.

Key Points

  • This study aims to investigate the relationship between coronary artery calcium and measures of subclinical cardiovascular disease in older adults without clinical cardiovascular disease.
  • Coronary artery calcium (CAC) assessed with electron beam tomography in 414 participants.
  • Participants examined for subclinical cardiovascular disease using ankle-arm index, ECG, or carotid ultrasound.
  • Receiver operating characteristic curves produced to evaluate the association between CAC and subclinical disease measures.
  • Internal carotid artery intima-media thickness correlated with CAC (r=0.30).
  • 17.5% of individuals with CAC ≥400 would be missed when using previous measures of subclinical atherosclerosis.
  • A low ankle-arm index was highly specific for a high CAC score.

Study Design

Type

Observational (n=414)

Structured PICO

How do measures of subclinical cardiovascular disease correlate with coronary artery calcium in older adults without clinical cardiovascular disease?

P
Population
414 community-dwelling older adults without clinical cardiovascular disease from the Cardiovascular Health Study
I
Intervention
Measures of subclinical cardiovascular disease (ankle-arm index, ECG, carotid ultrasound, internal carotid artery intima-media thickness)
O
Outcome
Relationship between coronary artery calcium (CAC) and other measures of subclinical cardiovascular diseasesurrogate

Main Result

Effect estimate: r=0.30

Internal carotid artery intima-media thickness is the subclinical measure most closely related to coronary artery calcium in older adults without clinical cardiovascular disease.

Cite This Study

Newman et al. (2002) conducted an observational in Subclinical cardiovascular disease (n=414). Coronary artery calcium assessment vs. Other measures of subclinical CVD (ankle-arm index, ECG, carotid ultrasound) was evaluated on Correlation between coronary artery calcium and internal carotid artery intima-media thickness (r=0.30). Internal carotid artery intima-media thickness was most strongly correlated with coronary artery calcium (r=0.30) in older adults without clinical cardiovascular disease.

synapsesocial.com/papers/6a0661179fae39ec6e2af3cehttps://doi.org/10.1161/01.atv.0000033540.89672.24
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