Key result
CAC score predicts ~69% higher cardiovascular risk per SD in CKD, outperforming CIMT and ABI.
Why the study?
Does the inclusion of coronary artery calcium score improve cardiovascular risk prediction beyond traditional Framingham predictors in individuals with CKD?
Cohort (n=6,553)
Does the inclusion of coronary artery calcium score improve cardiovascular risk prediction beyond traditional Framingham predictors in individuals with CKD?
Effect estimate: HR 1.69 (95% CI 1.45-1.97)
Coronary artery calcium score provides the greatest improvement in cardiovascular risk prediction beyond traditional risk factors in patients with chronic kidney disease compared to carotid intima-media thickness or ankle-brachial index.
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May enhance CKD risk stratification; leaves open impact on management or outcomes in prospective trials.
Matsushita et al. (2014) conducted a cohort in Chronic Kidney Disease (n=6,553). Coronary artery calcium score vs. Carotid intima-media thickness and ankle-brachial index was evaluated on Cardiovascular events (coronary heart disease, stroke, heart failure, and peripheral artery disease) (HR 1.69, 95% CI 1.45-1.97). Coronary artery calcium score improved cardiovascular risk prediction in subjects with CKD more than carotid intima-media thickness or ankle-brachial index (HR 1.69; 95% CI 1.45-1.97 per 1 SD).
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