Key result
Optimal antithrombotic therapy post-LAAC remains uncertain due to absent randomized trials and heterogeneous bleeding risks.
Why the study?
Uncertainty remains regarding the optimal post-implantation antithrombotic regimen following percutaneous LAAC due to an incomplete understanding of device healing, heterogeneous bleeding risk, and a lack of comparative randomized clinical trials.
This review highlights the current evidence, challenges, and future directions regarding optimal antithrombotic therapy following percutaneous left atrial appendage closure.
Optimal post-LAAC antithrombotic regimens remain uncertain; leaves open need for RCTs across bleeding-risk strata.
Percutaneous left atrial appendage closure (LAAC) has been established in clinical practice as an attractive alternative to oral anticoagulation for preventing stroke in patients with atrial fibrillation and high bleeding risk. The devices approved in Europe and United States (US) for percutaneous LAAC contain metal and antithrombotic therapy is strongly recommended after their implantation to prevent apposition of thrombus on the atrial surface of the device during endothelialization. However, there is still uncertainty regarding the optimal antithrombotic drug regimen following device implantation in view of the incomplete understanding of the LAAC device healing process, the lack of randomized clinical trials comparing different antithrombotic agents after LAAC and the heterogeneous bleeding risk of patients undergoing LAAC. Thus, this review aims to evaluate the available evidence and the remaining challenges related to the post-LAAC antithrombotic regimens. Furthermore, common clinical scenarios associated with challenging management of antithrombotic therapy after LAAC and potential future directions, will be discussed.
No takes yet. Share an insight, caveat, or question.
Galea et al. (2023) conducted a review in Atrial fibrillation with high bleeding risk undergoing left atrial appendage closure. Antithrombotic therapy post-LAAC was evaluated. Optimal antithrombotic therapy after percutaneous left atrial appendage closure remains uncertain due to a lack of randomized clinical trials and heterogeneous patient bleeding risks.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: