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June 27, 2026EP EuropaceOpen Access

For LAAC due to bleeding risk, DAPT was the most frequent discharge regimen (47.9%), while for stroke prevention, DOAC was preferred (41.1%).

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Why the study?

LAAC procedures lack standardized workflows and peri-procedural management, particularly regarding optimal post-procedural antithrombotic strategies.

Population

140 physicians from more than 20 countries

Design

Structured online questionnaire survey

Authors

LUL UrbanekPFP FutymaMMM Mazurek

Discussion

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Overview

Observed LAAC discharge variation warrants caution in practice; leaves open optimal regimens for randomized evaluation.

Key Points

  • This survey aims to capture current practices regarding antithrombotic strategies following left atrial appendage closure (LAAC) procedures across Europe.
  • Conducted a structured online questionnaire via European Heart Rhythm Association (EHRA) network and social media.
  • Included responses from 140 physicians across more than 20 countries.
  • Evaluated operator background, procedural setting, and antithrombotic regimens at discharge and follow-up.
  • 67.4% of respondents were electrophysiologists, mainly from university hospitals (44.9%).
  • Most centers reported an annual procedural volume of 1–20 LAAC procedures, predominantly for major bleeding (64.0%).
  • Dual antiplatelet therapy (DAPT) was most common for bleeding indications, while direct oral anticoagulation (DOAC) was preferred for stroke prevention (41.1%).

Structured PICO

P
Population
140 physicians from more than 20 countries (mostly electrophysiologists, 67.4%) participating in an EHRA survey on LAAC practice patterns.
I
Intervention
Online questionnaire on operator background, procedural setting, and antithrombotic regimens at discharge and follow-up for left atrial appendage closure (LAAC).
O
Outcome
Current practice patterns regarding LAAC procedures and post-procedural antithrombotic strategies.

There is substantial diversity in post-LAAC antithrombotic management across European centers, highlighting the need for standardized guidelines.

Cite This Study

Urbanek et al. (2026) studied this question.

synapsesocial.com/papers/6a3f97e8125782b61d865a88https://doi.org/10.1093/europace/euag105.388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contemporary European practice in left atrial appendage closure: results from a survey focusing on planning, techniques and post-implantation management2025 · 6 citations
  2. 2Antithrombotic Regimen After Percutaneous Left Atrial Appendage Closure　― A Real-World Study ―2023 · 11 citations
  3. 3ATRIAL FIBRILLATION AND PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE: A SINGLE–CENTER EXPERIENCE COMPARING DEVICES AND TECHNIQUES2026
  4. 4Antithrombotic Therapy after Percutaneous Left Atrial Appendage Closure: Evidence, Challenges and Future Directions2023 · 17 citations
  5. 5Left atrial appendage closure: Current status, unresolved issues, and future perspectives2025