Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 11, 2025Cardiovascular Intervention and TherapeuticsOpen Access

Left atrial appendage closure: Current status, unresolved issues, and future perspectives

View Full Paper
Ask AI
Bookmark
Share

Authors

YKYusuke KondoSRSatoko RyuzakiMNMiyo Nakano

Discussion

Loading...

Member takes

Overview

This review discusses stroke prevention and oral anticoagulation in patients undergoing left atrial appendage closure, indicating evolving strategies for antithrombotic therapy.

Key Points

  • To summarize the current status and future perspectives of left atrial appendage closure for stroke prevention.
  • Review of existing literature on left atrial appendage closure (LAAC) and its applications in atrial fibrillation (AF).
  • Analysis of procedural outcomes and challenges associated with devices like WATCHMAN and Amulet.
  • Consideration of antithrombotic strategies and integrated procedures involving LAAC and AF ablation.
  • LAAC is effective for stroke prevention in patients who cannot tolerate long-term oral anticoagulation.
  • Large clinical trials confirm that LAAC offers comparable efficacy to traditional anticoagulation with lower bleeding risks.
  • Device-related thrombus and peri-device leak remain critical concerns in LAAC procedures.

Cite This Study

Kondo et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f7844https://doi.org/10.1007/s12928-025-01222-6
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left atrial appendage closure: Current status, unresolved issues, and future perspectives2025
  2. 2Current methods of left atrial appendage closure: the non-pharmacological approach for stroke prevention in atrial fibrillation patients2023
  3. 3Percutaneous Left Atrial Appendage Closure: Current Evidence and Procedural Insights2025 · 1 citations
  4. 4Left atrial appendage closure devices: a contemporary review of techniques, tips and tricks2026
  5. 5The Next Frontiers in Stroke Prevention: Optimizing Left Atrial Appendage Closure in Atrial Fibrillation: Current Devices, Imaging-Guided Strategies, and Emerging Approaches2026