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December 11, 2025Cardiovascular Intervention and TherapeuticsOpen Access

Left atrial appendage closure: Current status, unresolved issues, and future perspectives

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Authors

YKYusuke KondoSRSatoko RyuzakiMNMiyo Nakano

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Overview

This review highlights emerging challenges in stroke prevention with left atrial appendage closure, indicating the importance of antithrombotic therapy.

Key Points

  • To review the current status, challenges, and future perspectives of left atrial appendage closure in stroke prevention.
  • Reviewed existing literature on LAAC
  • Discussed procedural safety and efficacy of WATCHMAN devices
  • Analyzed complications and antithrombotic strategies
  • LAAC provides effective stroke prevention comparable to oral anticoagulation
  • Concerns include device-related thrombus and peri-device leak
  • Intracardiac echocardiography reduces procedural complexity and anesthesia needs

Cite This Study

Kondo et al. (2025) studied this question.

synapsesocial.com/papers/69401b262d562116f28f794dhttps://doi.org/10.1007/s12928-025-01222-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left atrial appendage closure: Current status, unresolved issues, and future perspectives2025
  2. 2Current methods of left atrial appendage closure: the non-pharmacological approach for stroke prevention in atrial fibrillation patients2023
  3. 3Percutaneous Left Atrial Appendage Closure: Current Evidence and Procedural Insights2025 · 1 citations
  4. 4Left atrial appendage closure devices: a contemporary review of techniques, tips and tricks2026
  5. 5The Next Frontiers in Stroke Prevention: Optimizing Left Atrial Appendage Closure in Atrial Fibrillation: Current Devices, Imaging-Guided Strategies, and Emerging Approaches2026