Indications, evidence, and controversy in the closure of the left atrial appendage
Key result
LAAC holds a class IIb recommendation for stroke prevention in AF patients with OAC contraindications.
Why the study?
Does closure of the left atrial appendage prevent cardio-embolic stroke in patients with atrial fibrillation at high bleeding risk?
Population
Patients with atrial fibrillation at high bleeding risk or with contraindications to oral anticoagulant…
Design
Review
Authors
Discussion
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Member takes
Implication
Supports class IIb LAAO use in AF with OAC contraindications; leaves open need for randomized confirmation.
Structured PICO
Does closure of the left atrial appendage prevent cardio-embolic stroke in patients with atrial fibrillation at high bleeding risk?
P
Population
Patients with atrial fibrillation (AF) at high bleeding risk or with contraindications to oral anticoagulant therapy (CHA2DS2VASc score ≥2 in women and ≥1 in men)
I
Intervention
Closure of the left atrial appendage (LAAO)
O
Outcome
Prevention of cardio-embolic stroke
LAAO is a valid option (Class IIb recommendation) for stroke prevention in AF patients with high thromboembolic risk who have contraindications to oral anticoagulants.
Cite This Study
Patti et al. (2023) conducted a review in Atrial fibrillation. Left atrial appendage closure (LAAO) was evaluated. Left atrial appendage closure is a class IIb recommendation for stroke prevention in atrial fibrillation patients with contraindications to oral anticoagulants.