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January 1, 2018US Cardiology ReviewOpen Access

Left Atrial Appendage Closure Devices for Stroke Prevention in Patients with Non-Valvular AF

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Why the study?

Do left atrial appendage closure strategies improve safety and efficacy compared to pharmacological strategies in patients with non-valvular AF?

Population

Patients with non-valvular AF (NVAF)

Comparison

Left atrial appendage closure strategies vs Pharmacological strategies

Design

Review

Authors

DMDaniel McBrideTMTimothy M. MarkmanJLJackson J. Liang

Discussion

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Overview

Minimal evidence warrants caution against routine LAA occlusion in NVAF; leaves open need for randomized comparisons.

Structured PICO

Do left atrial appendage closure strategies improve safety and efficacy compared to pharmacological strategies in patients with non-valvular AF?

P
Population
Patients with non-valvular AF (NVAF)
I
Intervention
Left atrial appendage (LAA) closure strategies (percutaneous, thoracoscopic, and open closure)
C
Comparator
Pharmacological strategies (anticoagulation therapy)
O
Outcome
Safety and efficacy

Current evidence comparing LAA occlusion strategies to pharmacological therapy in NVAF is minimal, highlighting the need for further research.

Limitations

  • minimal evidence available

Cite This Study

McBride et al. (2018) studied this question.

synapsesocial.com/papers/6a7e652a1fdb7ee677c76ec0https://doi.org/10.15420/usc.2018.6.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Atrial Appendage Closure Devices For Stroke Prevention2014 · 7 citations
  2. 2Left Atrial Appendage Closure Devices For Stroke Prevention2011
  3. 3Left Atrial Appendage Closure Devices2014 · 25 citations
  4. 4Advances in Left Atrial Appendage Occlusion Strategies.2013 · 2 citations
  5. 5Left atrial appendage occlusion2014 · 14 citations