Key result
Successful LAAC is linked to altered acylcarnitine metabolism at six months.
Why the study?
Does successful left atrial appendage closure affect the metabolism of acylcarnitines in patients with atrial fibrillation?
Cohort
Does successful left atrial appendage closure affect the metabolism of acylcarnitines in patients with atrial fibrillation?
p-value: p=<0.05
Successful left atrial appendage closure alters acylcarnitine metabolism at six months, suggesting potential systemic metabolic effects of the procedure.
LAAC-associated acylcarnitine changes should not yet alter practice; leaves open whether these shifts affect AF outcomes or merit RCT confirmation.
BACKGROUND: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. METHODS: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. CONCLUSION: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02985463.
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Fastner et al. (2018) conducted a cohort in Atrial fibrillation (AF). Left atrial appendage closure (LAAC) vs. Baseline (immediately before LAAC) was evaluated on Metabolism of acylcarnitines (p=<0.05). Successful left atrial appendage closure (LAAC) significantly affected the metabolism of acylcarnitines at six months follow-up (P<0.05).
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