Beta-blockers exert effective antiarrhythmic actions and decrease mortality in postinfarct patients compared to other classes of antiarrhythmic agents.
Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situation or stress. On the other hand, sustained activation of cardiac β-receptors initiates maladaptive remodeling of the myocardium leading to cardiomyopathies and heart failure. Since both acute and chronic stimulation of β-adrenoceptors are arrhythmogenic, the application of β-receptor blockers exerts effective antiarrhytmic actions at both short and long time scale. Compared to other classes of antiarrhythmic agents, β-blockers are the class of antiarrhythmics that was shown to decrease mortality in postinfarct patients. Chemical, physiological, and pharmacological properties of the β-adrenoceptor related signaling, the role of β-1, β-2, and β-3 receptor subtypes, consequences of acute and long term β-adrenergic stimulation and the underlying proarrhythmic mechanisms, including the changes in cardiac ion currents and Ca(2+) handling, are reviewed in this paper together with the clinical relevance of cardioprotective β-blocking therapy.
Szentmiklósi et al. (Tue,) conducted a review in Arrhythmias and heart failure. Beta-blockers vs. Other antiarrhythmic agents was evaluated. Beta-blockers exert effective antiarrhythmic actions and decrease mortality in postinfarct patients compared to other classes of antiarrhythmic agents.