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December 1, 1996Circulation

Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart

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Authors

MSMichael N. SackNational Institutes of HealthTRToni A. RaderInsermSPSonhee ParkShaklee (United States)

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Implication

Metabolic gene shifts in failing hearts merit exploration; hypothesis-generating and leaves open whether FAO modulation improves clinical outcomes.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Sack et al. (1996) studied this question.

synapsesocial.com/papers/6a0662e13f8bf83a443dd97dhttps://doi.org/10.1161/01.cir.94.11.2837
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defective lipid metabolism in the failing heart1968 · 145 citations
  2. 2Switches in cardiac muscle gene expression as a result of pressure and volume overload1992 · 118 citations
  3. 3Myofibrillar adenosine triphosphatase activity in congestive heart failure1962 · 226 citations
  4. 4Effects of chronic right ventricular pressure overload on myocardial glucose and free fatty acid metabolism in the conscious rat1995 · 54 citations
  5. 5Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.1990 · 496 citations