Why the study?
Is transcatheter aortic valve implantation safe and effective in patients with bicuspid aortic valve stenosis?
Is transcatheter aortic valve implantation safe and effective in patients with bicuspid aortic valve stenosis?
TAVI appears safe and effective for bicuspid aortic stenosis, particularly with newer-generation devices, though pacemaker implantation rates remain a concern.
May support TAVI consideration in bicuspid aortic stenosis with newer devices; leaves open need for randomized data on pacemaker risk and durability.
Bicuspid aortic stenosis (AS) is not rare in patients treated with transcatheter aortic valve implantation (TAVI). Bicuspid valves have unique anatomy which could affect the results of TAVI; however, multiple recent reports have shown that TAVI is safe and effective in this population. Paravalvular aortic regurgitation was initially found to be more frequent in bicuspid patients, but newer-generation devices have shown superior results in this respect. Higher rates of pacemaker implantation after TAVI in bicuspid AS do require further investigation. Current data suggest that bicuspid valves should not be a contraindication for TAVI, but future specific trials are needed to support this assertion.
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Perlman et al. (2016) studied this question.
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