Key result
24-hour BP variability links to neurological and functional outcomes in acute ischemic stroke post-thrombolysis.
Why the study?
Does 24-hour blood pressure variability impact outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis?
Observational (n=28,976)
Yes
Does 24-hour blood pressure variability impact outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis?
p-value: p=<0.01
Individualized blood pressure management accounting for pre-treatment BP and acute BP variability may be needed to optimize outcomes in acute ischemic stroke patients undergoing thrombolysis.
No takes yet. Share an insight, caveat, or question.
Should not yet change BP targets in thrombolysis; hypothesis-generating for variability as modifiable factor.
Kellert et al. (2017) conducted an observational in Acute ischemic stroke (n=28,976). 24-hour blood pressure variability was evaluated on Early neurological improvement, symptomatic intracerebral hemorrhage, and long-term functional outcome (mRS at 90 days) (p=<0.01). 24-hour blood pressure variability significantly impacted clinical outcomes in acute ischemic stroke patients treated with intravenous thrombolysis (P<0.01).