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Investigate the physiological roles of gp130 and the effects of its deficiency on development.

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

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Investigate the physiological roles of gp130 and the effects of its deficiency on development.
Generation of gp130-deficient mice
Examination of embryonic development and organ morphology
Assessment of hematopoietic progenitor populations
Embryos lacking gp130 show progressive death between 12.5 days and term
Hypoplastic ventricular myocardium observed without structural defects
Reduced hematopoietic progenitors in the liver and T cells in the thymus, leading to anemia in some embryos

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Randomized trial investigates myocardial and hematological disorders in gp130-deficient mice, suggesting critical roles in development.

Yoshida et al. (1996) studied this question.

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