Population
Transgenic mice expressing a dominant negative mutant of gp130 in the heart under the control of alpha…
Comparison
Pressure overload vs Wild type (WT) mice subjected to pressure overload
Design
Preclinical
Authors
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gp130-STAT3 signaling mediates load-induced hypertrophy in mice; leaves open targeted inhibition for human disease.
gp130 plays a critical role in mediating pressure overload-induced cardiac hypertrophy, likely through the STAT3 signaling pathway.
Uozumi et al. (2001) studied this question.
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