Why the study?
Does cardiac-specific overexpression of DGKzeta attenuate pressure overload-induced cardiac hypertrophy and fibrosis in mice?
Population
Transgenic mice with cardiac-specific overexpression of DGKzeta and wild-type mice subjected to thoracic…
Comparison
Cardiac-specific overexpression of DGKzeta vs Wild-type (WT) mice
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports DGKzeta as protective in murine pressure-overload remodeling; hypothesis-generating for human HF therapies.
Does cardiac-specific overexpression of DGKzeta attenuate pressure overload-induced cardiac hypertrophy and fibrosis in mice?
Cardiac-specific overexpression of DGKzeta suppresses pressure overload-induced cardiac hypertrophy, fibrosis, and systolic dysfunction in a mouse model.
Harada et al. (2007) studied this question.