Why the study?
Does cardiac-specific overexpression of DGKε prevent cardiac hypertrophy and progression to heart failure under chronic pressure overload in mice?
Population
Transgenic mice with cardiac-specific overexpression of DGKε and wild-type mice subjected to continuous…
Comparison
Cardiac-specific overexpression of DGKε vs Wild-type (WT) mice
Design
Preclinical
Authors
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May attenuate hypertrophy and boost survival in overloaded mouse hearts; hypothesis-generating for DGKε-targeted HF therapy, pending translational studies.
Does cardiac-specific overexpression of DGKε prevent cardiac hypertrophy and progression to heart failure under chronic pressure overload in mice?
Cardiac-specific overexpression of DGKε prevents cardiac hypertrophy and improves survival under chronic pressure overload in mice, highlighting it as a potential therapeutic target for heart failure.
Niizeki et al. (2008) studied this question.
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