Key result
Severe CKD is linked to significantly reduced long-term survival in octogenarians undergoing PCI.
Why the study?
Does severe chronic kidney disease (creatinine clearance <30 ml/min) reduce long-term survival in octogenarian patients undergoing percutaneous coronary intervention?
Cohort (n=273)
No
Does severe chronic kidney disease (creatinine clearance <30 ml/min) reduce long-term survival in octogenarian patients undergoing percutaneous coronary intervention?
p-value: p=<0.0001
Severe chronic kidney disease (creatinine clearance <30 ml/min) is a strong predictor of reduced long-term survival in octogenarian patients undergoing percutaneous coronary intervention, regardless of whether the presentation is stable angina or acute coronary syndrome.
Severe CKD signals markedly poorer post-PCI survival in octogenarians; leaves open whether renal optimization improves prognosis.
OBJECTIVE: To evaluate the impact of chronic kidney disease on the survival of patients - 80 years of age undergoing percutaneous coronary intervention (PCI) in the long term. METHODS: 273 subjects who underwent PCI between January 2010 and January 2016 were divided into four categories: (1) stable angina (SA) and creatinine clearance - 30 (n=24); (2) patients with SA and CrCl <30 (n=70); (3) patients with acute coronary syndrome (ACS) and CrCl - 30 (n=51); (4) patients with ACS and ICC <30 (n=128). Mortality curves were evaluated using the Kaplan-Meier method and differences between groups were compared by log-rank statistic. Multivariate analysis was performed using the Cox proportional hazards method. The 4 groups were compared and the survival between the groups was evaluated. RESULTS: Octogenarian patients with CrCl <30 with SA and ACS have lower long-term survival (p<0.0001). CONCLUSION: CKD has a worse long-term prognosis for patients undergoing PCI.
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França et al. (2018) conducted a cohort in Coronary artery disease (n=273). Severe chronic kidney disease (Creatinine clearance <30 ml/min) vs. Creatinine clearance ≥30 ml/min was evaluated on All-cause mortality (p=<0.0001). Severe chronic kidney disease (creatinine clearance <30 ml/min) significantly reduced long-term survival in octogenarian patients undergoing percutaneous coronary intervention compared to those with clearance ≥30 ml/min.
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