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February 23, 2007Critical Care Medicine

Ventricular fibrillation frequency characteristics are altered in acute myocardial infarction

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Key result

Acute myocardial infarction significantly depressed ventricular fibrillation frequency characteristics compared with controls (p < .001), making them unsuitable surrogates for fibrillation duration.

Why the study?

Does acute myocardial infarction alter the frequency content of ventricular fibrillation compared to controls without coronary obstruction?

Population

27 swine

Comparison

Induction of acute myocardial infarction by… vs Control swine without coronary obstruction…

Design

Preclinical

Authors

JIJulia H. IndikRDRichard L. DonnersteinRBRobert A. Berg

Discussion

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Overview

Questions VF frequency as duration surrogate in AMI; hypothesis-generating for human AED algorithm validation.

Structured PICO

Does acute myocardial infarction alter the frequency content of ventricular fibrillation compared to controls without coronary obstruction?

P
Population
27 swine (11 with acute myocardial infarction induced by occlusion of the mid-left anterior descending artery, 16 control swine)
I
Intervention
Induction of acute myocardial infarction by occlusion of the mid-left anterior descending artery prior to ventricular fibrillation induction
C
Comparator
Control swine without coronary obstruction undergoing ventricular fibrillation induction
O
Outcome
Ventricular fibrillation waveform characteristics including mean, median, and dominant frequency, bandwidth, and amplitudesurrogate

Main Result

p-value: p=< .001

Acute myocardial infarction significantly alters the frequency content of ventricular fibrillation, suggesting these waveform characteristics are not reliable surrogates for VF duration in automated external defibrillators.

Cite This Study

Indik et al. (2007) studied Acute myocardial infarction and ventricular fibrillation (n=27). Induced acute myocardial infarction (mid-left anterior descending artery occlusion) vs. Control (no coronary obstruction) was evaluated on Ventricular fibrillation waveform frequency characteristics (mean, median, dominant frequency, bandwidth, and amplitude) (p=< .001). Acute myocardial infarction significantly depressed ventricular fibrillation frequency characteristics compared with controls (p < .001), making them unsuitable surrogates for fibrillation duration.

synapsesocial.com/papers/6a06641fcc83fae86177842ehttps://doi.org/10.1097/01.ccm.0000259540.52062.99
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