Key result
Lone atrial fibrillation was associated with a significantly greater rate of strokes compared to matched controls, demonstrating that it is not a benign condition.
Why the study?
Does lone atrial fibrillation increase the risk of new cardiovascular events in participants of the Framingham Study?
Population
5,209 participants in the Framingham Study, specifically focusing on 43 cases with 'lone' atrial…
Comparison
Lone atrial fibrillation (observational exposure) vs Matched controls from the remaining Framingham…
Design
Cohort
Follow-up
30 years
Authors
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Lone AF may warrant closer stroke surveillance; leaves open optimal prevention strategies pending randomized trials.
Case-Control (n=5,209)
Does lone atrial fibrillation increase the risk of new cardiovascular events in participants of the Framingham Study?
Lone atrial fibrillation is not a benign condition and is associated with a significantly increased risk of stroke, indicating a greater need for detection and treatment.
Frederick N. Brand (1985) conducted a case-control in Lone atrial fibrillation (n=5,209). Lone atrial fibrillation vs. Matched controls from the remaining Framingham sample was evaluated on New cardiovascular events (coronary heart disease, congestive heart failure, and strokes). Lone atrial fibrillation was associated with a significantly greater rate of strokes compared to matched controls, demonstrating that it is not a benign condition.
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