Key result
Obesity cuts adipose tissue vessel density by ~51% and enlarges adipocytes in mice.
Why the study?
Application of systems biology approaches to VEGF-A signaling in obesity is limited by scattered and contradictory data regarding the adipose vascular microenvironment.
Design
Comprehensive analysis of existing literature and data mining
Authors
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Standardizes parameters for adipose angiogenesis models; hypothesis-generating for human obesity-related vascular changes.
This comprehensive literature analysis provides standardized parameters on adipose vascular morphology and VEGF-A signaling to support systems biology modeling for obesity-induced angiogenesis.
Lee et al. (2025) studied this question. Obesity increases adipocyte size by 78% and decreases adipose tissue vessel density by 51% in mice, with vessels being 47% to 58% smaller.
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