Why the study?
Does modulation of VEGF-A activity improve adipose tissue function and insulin resistance in mouse models of obesity?
Does modulation of VEGF-A activity improve adipose tissue function and insulin resistance in mouse models of obesity?
The metabolic consequences of modulating angiogenic activity in adipose tissue are context-dependent, offering protective effects during expansion but requiring antiangiogenic action to improve preexisting dysfunction.
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Stage-specific VEGF-A effects in obese mice warrant caution on timing; leaves open human translation for metabolic disease.
Sun et al. (2012) studied this question.
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