Key result
Brown adipocyte-specific VEGF-A overexpression increased vascularization and thermogenesis, and improved glucose and lipid metabolism in diet-induced obese mice.
Why the study?
Does brown adipocyte-specific VEGF-A overexpression improve thermogenesis and metabolic function in mice?
Population
Doxycycline-inducible, brown adipocyte-specific VEGF-A transgenic overexpression mouse model, including…
Design
Preclinical
Authors
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No clinical translation yet from this mouse model; leaves open VEGF-A targeting in BAT for human metabolic disease.
Does brown adipocyte-specific VEGF-A overexpression improve thermogenesis and metabolic function in mice?
VEGF-A overexpression in brown adipose tissue promotes vascularization, thermogenesis, and metabolic improvements in diet-induced obese mice.
Sun et al. (2014) studied Diet-induced obesity and cold tolerance. Brown adipocyte-specific VEGF-A transgenic overexpression was evaluated on Vascularization, thermogenesis, and glucose/lipid metabolism. Brown adipocyte-specific VEGF-A overexpression increased vascularization and thermogenesis, and improved glucose and lipid metabolism in diet-induced obese mice.
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