Key result
Autonomic dysfunction with gastrointestinal and thermoregulatory symptoms is linked to elevated anxiety and depression.
Why the study?
Autonomic dysfunction is prevalent in Parkinson disease and can worsen quality of life, but its associations with mood symptoms and mood trajectories were unclear.
Is autonomic dysfunction associated with mood symptoms and trajectories in de novo Parkinson's disease patients?
Cohort (n=414)
Is autonomic dysfunction associated with mood symptoms and trajectories in de novo Parkinson's disease patients?
p-value: p=<.001
Autonomic dysfunction, specifically gastrointestinal and thermoregulatory symptoms, may serve as an early indicator for elevated anxiety and depression in Parkinson's disease.
May flag mood risk in early PD; hypothesis-generating for autonomic-targeted trials.
BACKGROUND: Autonomic dysfunction is prevalent in Parkinson's disease (PD) and can worsen quality of life. We examined: (a) whether specific autonomic symptoms were more strongly associated with anxiety or depression in PD and (b) whether overall autonomic dysfunction predicted mood trajectories over a 5-year period. METHODS: = 414) from the Parkinson's Progression Markers Initiative completed self-report measures of depression, anxiety, and autonomic symptoms annually. Cross-sectional linear regressions examined relationships between specific autonomic subdomains (gastrointestinal, cardiovascular, thermoregulatory, etc.) and mood. Multilevel modeling examined longitudinal relationships with total autonomic load. RESULTS: < .001). CONCLUSION: Findings suggest autonomic dysfunction, particularly gastrointestinal and thermoregulatory symptoms, may be an indicator for elevated anxiety/depression and a potential treatment target early on in PD.
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Ratajska et al. (2023) conducted a cohort in De Novo Parkinson's Disease (n=414). Autonomic dysfunction was evaluated on Mood trajectories (anxiety or depression) (p=<.001). Autonomic dysfunction, particularly gastrointestinal and thermoregulatory symptoms, was significantly associated with elevated anxiety and depression over a 5-year period (P<0.001).
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