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May 15, 2026EFSA JournalOpen Access

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

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Authors

NNNovel Foods and Food Allergens (NDA) EFSA Panel on NutritionDTDominique TurckTBTorsten Bohn

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Implication

Randomized trial evaluates safety and bioavailability of beta-nicotinamide mononucleotide in adults, suggesting its safety for use in food supplements.

Key Points

  • To assess the safety and bioavailability of β-NMN as a novel food source of niacin.
  • Evaluation based on Regulation (EU) 2015/2283
  • Human intervention study comparing bioavailability of β-NMN and nicotinamide
  • 90-day oral toxicity study in rats
  • No safety concerns regarding β-NMN identified for adult use under proposed conditions
  • Bioavailability of nicotinamide from β-NMN determined to be equivalent with a conversion factor of 1
  • NOAEL identified at 400 mg/kg bw per day with MoE of 93

Cite This Study

Nutrition et al. (2026) studied this question.

synapsesocial.com/papers/6a06b74ce7dec685947aa3c5https://doi.org/10.2903/j.efsa.2026.10007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Scientific Opinion on Dietary Reference Values for energy2013 · 261 citations
  2. 2Guidance on scientific principles and data requirements for the safety and relative bioavailability assessment of new micronutrient sources2024 · 10 citations
  3. 3β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats2016 · 25 citations
  4. 4Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled , double‐blind study2022 · 35 citations
  5. 5The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial2022 · 172 citations