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May 15, 2026Journal of Surgical ResearchOpen Access

Intrapleural Fibrinolytic Therapy for Pediatric Empyema: What Is the Proper Regimen?

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Authors

WEWest ErinSSSchermerhorn SophiaCAClaire Allison

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Overview

Randomized trial evaluates dosing regimens for intrapleural fibrinolytic therapy in children with empyema, suggesting optimal treatment duration.

Key Points

  • The aim is to determine the most effective dosing regimen for intrapleural fibrinolytic therapy in pediatric empyema.
  • Reviewed records of all patients with empyema who underwent chest tube placement and tPA installation from 2012 to 2024.
  • Excluded patients with pleural collections due to chylothorax, malignancy, or cardiac surgery.
  • Grouped patients by duration and timing of fibrinolytic therapy, assessing chest tube duration and complications.
  • Sixty-five patients (58%) received consecutive doses of tPA; those receiving 3 days had the shortest chest tube duration at 6 days (P = 0.013).
  • Consecutive therapy led to shorter chest tube duration (6 days) compared to selective therapy (9.5 days) (P = 0.002).
  • Three (2.7%) patients required operative decortication.

Cite This Study

Erin et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7a1e7dec685947aa636https://doi.org/10.1016/j.jss.2026.03.105
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