Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 21, 2026Respiration

Intrapleural Fibrinolytics use in Children with Pleural Empyema: Safe and Effective

View Full Paper
Ask AI
Bookmark
Share

Authors

CJCarmen C.M. de JongIHIlia E. HeijtingPMPeter Merkus

Discussion

Loading...

Member takes

Overview

Randomized trial assesses intrapleural fibrinolytics efficacy in children with pleural empyema, implying a less invasive approach.

Key Points

  • The study aims to evaluate the effectiveness and safety of intrapleural fibrinolytics in avoiding video-assisted thoracoscopy (VATS) in children with pleural empyema.
  • Included children referred for chest drainage of pleural effusion from 01-2022 to 04-2023
  • Evaluated symptoms, imaging results, and treatment outcomes
  • Analyzed the effect of intrapleural fibrinolytics on persistent pleural effusion cases.
  • 33 children aged 0-16 years were treated for pleural effusion, with 72% showing fever, cough, and dyspnea
  • 14 (52%) of 27 children with chest drains received intrapleural fibrinolytics, avoiding VATS in most cases
  • No side effects from treatment were observed and overall treatment appears effective.

Cite This Study

Jong et al. (2026) studied this question.

synapsesocial.com/papers/6a3781db24f042ddf4c5b78dhttps://doi.org/10.1159/000553095
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intrapleural Fibrinolytic Therapy in the Management of Pediatric Pleural Empyema: A Narrative Review2026
  2. 2Video-Assisted Thoracoscopic Surgery Versus Tube Thoracostomy with Fibrinolytics for Treatment of Empyema in Children: A Meta-Analysis of Randomized Controlled Studies2025 · 4 citations
  3. 3A retrospective study to evaluate the safety and efficacy of intrapleural alteplase in pediatric empyema2024 · 2 citations
  4. 4The role of the early video-assisted thoracoscopic surgery in children with pleural empyema2024 · 8 citations
  5. 5Intrapleural Fibrinolytic Therapy for Pediatric Empyema: What Is the Proper Regimen?2026