Discovery of 4-carboxylate-1,2,3-triazine 1-oxide, their 1,2,3-triazine, and the 3,6-dihydro analogs, as new agents against Chagas diseases and Leishmaniasis

= 0.46 μM) similar to miltefosine against promastigotes of L. mexicana, and 1,2,3-triazine (2i) reduced parasitemia by up to 70 % in an in vivo mouse model. These results are the first report of 4-carboxylate-1,2,3-triazine 1-oxides and their deoxygenated and reduced analogs as trypanocidal and leishmanicidal agents, encouraging their use for the development of new therapeutic alternatives against these neglected parasitic diseases.