Experiments reveal proanthocyanidin interactions affect anti-inflammatory responses in RAW264.7 cells, indicating significance for protein-ligand dynamics.
a = 283.7 L/mol) with LcTLP. Thermodynamic parameters indicated hydrogen bonding as dominant, reflecting an enthalpy-driven process. In RAW264.7 cells, PAPC more effectively suppressed LcTLP-induced NO, TNF-α, and IL-6 secretion by coating LcTLP surface. However, oligomeric proanthocyanidins occupied LcTLP active site by binding to the key residues, including GLU84 and TYR85.
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Li et al. (2026) studied this question.
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