The elusive endo-product of the archetypal Diels-Alder reaction of furan and maleic anhydride – observed in the solid state at last

Cameron B. Lennox; Christopher Taylor; Igor Huskić; Jogirdas Vainauskas; Christopher Nickels; Robin S. Stein; Tristan H Borchers; A.R. Bonnie J. Lutton Gething; Joseph M. Marrett; Graeme M. Day; Tomislav Friščić

doi:10.1039/d5sc06724c

January 1, 2026Chemical ScienceOpen Access

The elusive endo-product of the archetypal Diels-Alder reaction of furan and maleic anhydride – observed in the solid state at last

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Key Points

This research aims to elucidate the elusive endo-product of the Diels-Alder reaction between furan and maleic anhydride.
Utilized solid-state analysis technique to observe the endo-product.
Performed Diels-Alder reaction using furan and maleic anhydride.
Assessed the results through various chemical characterization methods.
The endo-product was successfully observed in the solid state, highlighting its stability.
Demonstrated deviations from the Alder endo-rule, indicating unique reactivity patterns.
Provided structural insights that could enhance understanding of Diels-Alder mechanisms.

Implication

Reveals endo-product of Diels-Alder reaction in solid state, suggesting its significance in organic synthesis.

Abstract

The [4+2] reaction of furan and maleic anhydride is an archetypal, textbook example of Diels-Alder reactivity, whose role as an early and prominent exception from the Alder endo-rule has made...

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Cite This Study

Lennox et al. (2026) studied this question.

synapsesocial.com/papers/6a06b86ae7dec685947aad74 https://doi.org/10.1039/d5sc06724c

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The elusive endo-product of the archetypal Diels-Alder reaction of furan and maleic anhydride – observed in the solid state at last

Key Points

Implication

Abstract

Discussion

Cite This Study

The elusive endo-product of the archetypal Diels-Alder reaction of furan and maleic anhydride – observed in the solid state at last

Key Points

Implication

Abstract

Discussion

Cite This Study

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