What question did this study set out to answer?

The aim was to develop and validate an eco-friendly method for the simultaneous determination of ornidazole and ofloxacin.

May 15, 2026Open Access

Development and validation of a hydrotropic UV–Visible spectrophotometric method for the simultaneous assay of ornidazole and ofloxacin tablets

View Full Paper

Ask AI

Bookmark

Authors

LSLuc ShabaniInstitut Supérieur de Technique Médicale MNMichel NTAMBWE NGOYIKinshasa General Hospital BTBaruti Emile TweniUniversité de Kisangani

Discussion

Member takes

Implication

Randomized trial demonstrates a new method for analyzing ofloxacin and ornidazole in pharmaceuticals, indicating improved quality control in resource-limited settings.

Key Points

The aim was to develop and validate an eco-friendly method for the simultaneous determination of ornidazole and ofloxacin.
Used a ternary mixture (10% urea/10% nicotinamide, w/v) for solubilization.
Applied a bathochromic shift method at pH 9.5 with NaOH.
Validated following ICH Q2(R2) guidelines using a Total Error approach.
Demonstrated linearity with R² = 0.9923 for ornidazole and R² = 0.9913 for ofloxacin.
Mean recovery rates were 99.61% for ornidazole and 99.95% for ofloxacin.
Assay results confirmed compliance with pharmacopoeial specifications.

Cite This Study

Shabani et al. (2026) studied this question.

synapsesocial.com/papers/6a06b888e7dec685947aaf25 https://doi.org/10.4314/orapj.v7i4.32

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial demonstrates a new method for analyzing ofloxacin and ornidazole in pharmaceuticals, indicating improved quality control in resource-limited settings.

Development and validation of a hydrotropic UV–Visible spectrophotometric method for the simultaneous assay of ornidazole and ofloxacin tablets

Discussion

Member takes

Implication

Key Points

Cite This Study

Development and validation of a hydrotropic UV–Visible spectrophotometric method for the simultaneous assay of ornidazole and ofloxacin tablets

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider