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This research aims to identify the phytochemical composition and evaluate the biological activities of different organs of Cannabis sativa L.

May 15, 2026Open ChemistryOpen Access

Comparative analysis of phytochemical profile and bioactivities of Cannabis sativa L. organs: insights into α -amylase inhibition, anti-inflammatory activity, antibacterial and antifungal effect

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Randomized trial investigates bioactive compounds and their effects in Cannabis sativa L. organs, suggesting therapeutic potential.

This research aims to identify the phytochemical composition and evaluate the biological activities of different organs of Cannabis sativa L.
Phytochemical profile assessed by quantifying polyphenols, flavonoids, and tannins.
Gas Chromatography–Mass Spectrometry (GC-MS) used for identifying major bioactive compounds.
Antimicrobial testing performed against four bacterial and four fungal strains; anti-inflammatory activity evaluated using the BSA denaturation assay.
Flower extract demonstrated the strongest antimicrobial effect among different organ extracts.
Highest anti-inflammatory activity noted in the flower extract (IC50 = 472.7 ± 11 μg/mL).
Leaf extract showed the most potent α-amylase inhibition (IC50 = 138 ± 5 μg/mL) with confirmed potential via molecular docking.

El-Mernissi et al. (2026) studied this question.

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