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May 15, 2026Open Access

Arginases and L-arginine metabolism in the pathogenesis of chronic cutaneous leishmaniasis

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Authors

BRBaplu RaiFriedrich-Alexander-Universität Erlangen-Nürnberg

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Implication

Randomized trial explores arginase role in chronic cutaneous leishmaniasis, suggesting dietary L-arginine as a treatment option.

Key Points

  • This research investigates the role of arginase 1 and arginase 2 in chronic cutaneous leishmaniasis pathology.
  • C57BL/6N wild-type and knockout mice were infected with L. mexicana
  • Blocking antibodies were administered to inhibit IFNγ response during infection
  • Flow cytometry and transcriptomics analyses were performed on skin lesions and lymph nodes.
  • C57BL/6 WT mice showed non-healing lesions while Arg1ΔTek and Arg2-/- mice developed mild pathology.
  • Elevated ARG1 expression led to L-arginine depletion in WT mice, driving chronic disease.
  • Oral L-arginine supplementation prevented chronic CL and cured established lesions.

Cite This Study

Baplu Rai (2024) studied this question.

synapsesocial.com/papers/6a06b8f8e7dec685947ab75dhttps://doi.org/10.25593/open-fau-637
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral L-arginine cures arginase 1-dependent chronic cutaneous leishmaniasis by redirecting the T helper cell response2025
  2. 2Impaired lymphatic remodeling leads to immunopathology during non-healing cutaneous leishmaniasis 43762025
  3. 3Beyond the parasite: skin-intrinsic cytolytic circuits drive disease in cutaneous leishmaniasis and reveal targets for host-directed therapy2026
  4. 4Transcriptomic and macrophage polarization signatures define anergic diffuse and mucosal forms of severe American cutaneous leishmaniasis2026
  5. 5Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response2025 · 1 citations