What question did this study set out to answer?

Network Pharmacology, Machine Learning, Molecular Docking, and Cell Experiments Reveal the Therapeutic Mechanism of Radix Rehmanniae Praeparata in Psoriasis In Vitro

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial analyzes therapeutic effects of Radix Rehmanniae Praeparata in psoriasis, implying multi-target treatments.

This study aims to explore the therapeutic mechanism of Radix Rehmanniae Praeparata in treating psoriasis.
Used network pharmacology to identify active ingredients and target interactions.
Applied machine learning algorithms like LASSO and SVM-RFE to screen for significant targets.
Conducted in vitro experiments using human keratinocytes to validate findings.
Identified Sitosterol and Stigmasterol as active ingredients with 145 targets for RRP and 18,871 targets for psoriasis.
LASSO and SVM-RFE highlighted RORC and HSD11B1 as core targets.
Cell experiments revealed that Stigmasterol reduces HaCaT proliferation and inflammation via HSD11B1 upregulation.

Zhang et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark