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November 18, 2025Scientific ReportsOpen Access

Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation

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Authors

JLJia LiuCTCheng TanJSJianxin Shi

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Overview

Experimental validation demonstrates therapeutic effects of Notopterygii rhizoma et radix in psoriasis, indicating its multi-target potential.

Key Points

  • To elucidate the pharmacological mechanism of Notopterygii rhizoma et radix in treating psoriasis.
  • Validated QH effects on Imiquimod-induced psoriasis-like mice.
  • Utilized LPS-induced keratinocyte model (HaCaT) for additional verification.
  • Explored potential mechanisms using network pharmacology to identify signaling pathways.
  • QH significantly alleviated skin symptoms in animal models.
  • Confirmed inhibition of HaCaT proliferation and reduction in inflammation.
  • Highlighted modulation of PI3K/Akt/mTOR pathway as a new therapeutic avenue.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6924fef4c0ce034ddc351c77https://doi.org/10.1038/s41598-025-20133-3
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