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September 10, 2025MedicineOpen Access

Network pharmacology and Mendelian randomization analysis of Xiao Bi decoction in treating psoriasis

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Authors

WHWentao HuYJYifang JiangJWJie Wang

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Overview

Analysis reveals causal relationships between active components and psoriasis outcomes, suggesting effective targets for treatment.

Key Points

  • Xiao Bi decoction contains 171 active components, with quercetin and dihydrobaicalin _qt among the top contributors.
  • Network pharmacology identified core targets like tumor necrosis factor and interleukin-6, crucial in psoriasis management.
  • Mendelian randomization analysis indicated a causal link between reduced IL-6 levels and higher psoriasis risk.
  • Findings support the scientific validation of Xiao Bi decoction in treating psoriasis by targeting key molecular mechanisms.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa356https://doi.org/10.1097/md.0000000000044173
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