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May 24, 2026Chinese MedicineOpen Access

Integrating network pharmacology, transcriptomics, and experimental validation: Compound Baixianpi Formula targets IL-17A to inhibit dual PI3K-AKT/JAK2-STAT3 pathways for psoriasis improvement

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Authors

LTLin TangYWYue WangYZYue Zhou

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Overview

Randomized trial evaluates the effects of Baixianpi Formula on psoriasis, targeting IL-17A and key signaling pathways.

Key Points

  • This research aims to uncover the mechanisms by which Compound Baixianpi Formula improves psoriasis through targeting IL-17A.
  • Utilized UHPLC-Q-Orbitrap HRMS to identify FFBXP components.
  • Conducted in vivo and in vitro experiments using IMQ mouse model and TNF-α-stimulated HaCaT cells.
  • Validated findings through molecular docking, qRT-PCR, Western blot, and immunofluorescence techniques.
  • FFBXP improved erythema and reduced skin lesion infiltration in psoriatic mice (p<0.01).
  • Significantly decreased inflammatory cytokines (IL-17A, IL-23, TNF-α) and oxidative stress markers (MDA) in treated groups (p<0.05).
  • Confirmed inhibition of IL-17A expression and phosphorylation of signaling proteins PI3K, AKT, JAK2, and STAT3.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/6a12966a48a0ea1665673306https://doi.org/10.1186/s13020-026-01386-0
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