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March 7, 2026Journal of EthnopharmacologyOpen Access

Integrating network pharmacology and experimental validation to elucidate the mechanism of Xiao-bi decoction in psoriasis treatment: Inhibition of JAK2/STAT3 signaling and rebalancing Th17/Treg responses

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Authors

CWChanghui WenXYXiaoqiong YangYHYue Han

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Overview

Network pharmacology reveals how Xiao-bi decoction improves psoriasis by regulating Th17/Treg balance.

Key Points

  • To understand the mechanism of Xiao-bi decoction in treating psoriasis, particularly focusing on its effects on JAK2/STAT3 signaling and Th17/Treg balance.
  • Established a psoriasis model in mice using imiquimod.
  • Evaluated psoriasis severity and immune cell infiltration.
  • Utilized network pharmacology and transcriptome sequencing to analyze components and mechanisms.
  • Conducted ELISA, western blotting, and molecular docking for validation.
  • XBD significantly alleviated psoriatic symptoms such as erythema and scaling.
  • Reduced CD4 + T cell infiltration and serum levels of pro-inflammatory cytokines.
  • Increased levels of regulatory T cells (FoxP3 +) while decreasing pro-inflammatory Th17 cells.
  • Inhibited JAK2/STAT3 signaling pathway and rebalanced Th17/Treg cells.

Cite This Study

Wen et al. (2026) studied this question.

synapsesocial.com/papers/69abc0b85af8044f7a4e96f8https://doi.org/10.1016/j.jep.2026.121477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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