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August 15, 2025Combinatorial Chemistry & High Throughput Screening

Hua-Zhuo-Ning-Fu Decoction Ameliorates Psoriasis by Inhibiting TNF-Α/IL-6 and PI3K/AKT Signaling Pathway: A Network Pharmacology Approach and Experimental Validation

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Authors

ZWZhuzhu WuWMWenke MaZGZhaoyizhu Guan

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Overview

Network pharmacology analysis reveals HZD targets TNF-α and IL-6 in psoriasis, suggesting therapeutic potential.

Key Points

  • HZD significantly reduced inflammation and oxidative stress in M5-stimulated HaCaT cells, enhancing its anti-psoriasis capabilities.
  • Key findings indicate that HZD inhibited the expression of TNF-α and IL-6 while affecting the PI3K/AKT pathway.
  • Molecular docking validated that key components of HZD effectively interact with target proteins, including IL-6 and TNF-α.
  • Animal models confirmed that HZD alleviated psoriatic dermatitis and inflammatory responses, reinforcing its traditional use.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbb67https://doi.org/10.2174/0113862073390038250723201614
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Also Consider

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